Since 2004 Lea landed her own movie series produced by Hallmark - Jane Doe. Ten mystery movies about average houswife that helps security agency solve mysteries were produced.
In 2007 she played in based on true story movie A Life Interrupted - drama based on life of Debbie Smith and her trauma after being raped near her house. Smith started the fight with the system to help other rape victims. Lea played the main character.
In 2010 she was one of the stars on reunion of Back To The Future cast on 25th anniversary of the first movie premiere. Also the same year she took part in sorf-of reunion with 3 of the actors from Caroline in the City when they played together in Adventures of a Teenage Dragonslayer.
In 2011 she took a part in TV series Switched at Birth and the same year she was joined by her daughters in a movie Mayor Cupcake where Madelina and Zoey played her daughters.
Lea Thompson lives together with her husband and two daughters, Madeline and Zoey, in San Fernando Valley, Los Angeles, California.